When Betty Anne Waters' older brother Kenny is arrested for murder and sentenced to life in 1983, Betty Anne, a Massachusetts wife and mother of two, dedicates her life to overturning the murder conviction. Convinced that her brother is innocent, Betty Anne puts herself through high school, college and, finally, law school in an 18 year quest to free Kenny. With the help of best friend Abra Rice, Betty Anne pores through suspicious evidence mounted by small town cop Nancy Taylor, meticulously retracing the steps that led to Kenny's arrest. Belief in her brother - and her quest for the truth - pushes Betty Anne and her team to uncover the facts and utilize DNA evidence with the hope of exonerating Kenny.

Notorious serial killer Joe Carroll, after being found guilty of murdering 14 female students on the Virginia college campus where he taught literature, escapes from death row. The FBI calls former agent Ryan Hardy to consult on the case, as he was the one responsible for Carroll’s capture in 2003. Ryan, working closely with an FBI team, including Mike Weston and FBI Specialist Debra Parker, piece together the ever-growing web of murders orchestrated by the devious Carroll.