Morioh, 1999—a normally quiet and peaceful town has recently become a hotbed of strange activity. Jōtarō Kūjō, now a marine biologist, heads to the mysterious town to meet Jōsuke Higashikata. While the two may seem like strangers at first, Jōsuke is actually the illegitimate child of Jōtarō's grandfather, Joseph Joestar. When they meet, Jōtarō realizes that he may have more in common with Jōsuke than just a blood relation. Along with the mild-mannered Kōichi Hirose and the boisterous Okuyasu Nijimura, the group dedicates themselves to investigating recent disappearances and other suspicious occurrences within Morioh. Aided by the power of Stands, the four men will encounter danger at every street corner, as it is up to them to unravel the town's secrets, before another occurs.

After failing to avenge her father's murder, Princess Scarlet, wakes up in the "Land of the Dead." In this world filled with madness, if she does not achieve her revenge against her nemesis and reach the "No End Place," she will become "Void" and cease to exist. Can Scarlet find a way to live at the end of her endless journey?