Ten years after the Ceremonial Battle, a teenage boy named Judai Yuuki (Jaden Yuki) heads off in order to join the Duel Academia (Duel Academy) located on a remote island off the coast of Japan. There he meets his fellow students and gains a few friends, along with a few enemies. Judai is put into the lowest rank of Osiris Red (Slifer Red), but he continues to test his skills against the students and faculty to prove his worth as a Duelist and earn the respect of everyone around him.

The dark fantasy follows a high school sophomore named Akihito Kanbara. Although the boy appears human, he is half Youmu and invulnerable to wounds because he can heal quickly. One day, Akihito meets freshman Mirai Kuriyama when it seems she is about to jump from the school rooftop. Mirai is isolated because of her ability to manipulate blood, which is considered heresy among members of the spirit world. Disturbing events begin to unfold after Akihito saves Mirai.

Beginner blader Robin Kazami joins up with influencer Multi Nana-iro and former champion Jaxon Cross to form this unlikely trio - ready to climb to the top of The X and win the title of champion blader!

Kate Diamond owns the Roaring Falls Trading Post from where she directs her gang's gun-smuggling to the Indians. After she short-changes smuggler Stacey, his men attempt to steal the hidden guns, and attack her foreman Nebraska, but he is saved by Jimmy and "Cannonball" on their way to file a homestead claim at Canyon City. Jimmy renews a long acquaintance with Sheriff Harris and his daughter Jessica. The sheriff is wounded by half-breed Danny when he finds a rifle hidden in the latter's wagon, but Jimmy captures the outlaw, a go-between for Kate and the Indians.Wounded and in bed, Sheriff Harris ask Jimmy not to tell Jessica that she is only adopted and that Nebraska is really her father, although he believes her to be dead.