Sterling Archer is the world's most daunting spy. He works for ISIS, a spy agency run by his mother. In between dealing with his boss and his co-workers - one of whom is his ex-girlfriend - Archer manages to annoy or seduce everyone that crosses his path. His antics are only excusable because at the end of the day, he still somehow always manages to thwart whatever crises was threatening mankind.

The series follows Bob who runs Bob's Burgers, with the help of his wife and their three kids. Bob has big ideas about burgers, but the rest of the clan falls short on service. Despite the greasy counters and lousy location, the Belchers are determined to make every "Grand Re-Re-Re-opening" a success. Bob's wife, Linda, stands by her man and often does so by bursting into song. Their eldest daughter, 13-year-old Tina has a slight obsession with boys and zombies. Middle child Gene is an aspiring musician with a thirst for life. Louise is the bunny ears-wearing youngest daughter with an off-kilter sense of humor that makes her somewhat of a liability in the kitchen – and with the public.

A documentary team gets a grant to do a film on a rare fatal disease that is attacking homeless people. However, they quickly find the film too depressing. Ducking into a nightclub, they discover a young Manhattan comedienne and decide instead to follow her as she makes the circuit of auditions in L.A. as she tries to get a TV pilot. Unfortunately, she has failed to tell her boyfriend of this move. He decides he will trail her out west. There, the boyfriend runs into an old friend who has already made a break on a TV pilot. Seizing the opportunity, the actress turns her attentions to the established actor. However, the actress goes nowhere in auditions, but her ex-boyfriend is suddenly noticed and becomes the next hot prospect.